Paket Lengkap Synthesis And Antimicrobial Evaluation Of 2-[(Substituedphenyl)-5-(1-Phenyl-3-(Piperazinyl)Pyrido[3,2-F]Quinazolin-4(1H)-Yl]-1,3,4-Thiadiazoles - Hallo sahabat Paket Lengkap Pendidikan Dasar, Pada Artikel yang anda baca kali ini dengan judul Paket Lengkap Synthesis And Antimicrobial Evaluation Of 2-[(Substituedphenyl)-5-(1-Phenyl-3-(Piperazinyl)Pyrido[3,2-F]Quinazolin-4(1H)-Yl]-1,3,4-Thiadiazoles, kami telah mempersiapkan artikel ini dengan baik untuk anda baca dan ambil informasi didalamnya. mudah-mudahan isi postingan Artikel Jp Farmasi gg 2016, Artikel Jp Farmasi gg 2018, yang kami tulis ini dapat anda pahami. baiklah, selamat membaca.

Judul : Paket Lengkap Synthesis And Antimicrobial Evaluation Of 2-[(Substituedphenyl)-5-(1-Phenyl-3-(Piperazinyl)Pyrido[3,2-F]Quinazolin-4(1H)-Yl]-1,3,4-Thiadiazoles
link : Paket Lengkap Synthesis And Antimicrobial Evaluation Of 2-[(Substituedphenyl)-5-(1-Phenyl-3-(Piperazinyl)Pyrido[3,2-F]Quinazolin-4(1H)-Yl]-1,3,4-Thiadiazoles

Paket Lengkap Synthesis And Antimicrobial Evaluation Of 2-[(Substituedphenyl)-5-(1-Phenyl-3-(Piperazinyl)Pyrido[3,2-F]Quinazolin-4(1H)-Yl]-1,3,4-Thiadiazoles

Abstract: Several novel 2-[(substitutedphenyl)-5-(1-phenyl-3-(piperazinyl)pyrido[3,2-f] quinazolin-4(1H)-yl]-1,3,4 thiadiazole derivatives have been designed and synthesised by incorporating  four  known moieties  such  as  2-methylquinolin-5-ol, acetophenone, urea and 3-substitutedphenyl-4-amino-5-mercapto triazoles by using multi-step conventional reaction strategy. The synthesized derivatives were characterized by IR, 1H-NMR, Mass and elemental analysis (C, H, N). Furthermore the synthesized 2-[(substitutedphenyl)-5-(1-phenyl-3-(piperazinyl)pyrido[3,2-f]quinazolin-4(1H)-yl]-1,3,4-thiadiazoles 4a-g were screened for antibacterial and antifungal activities. The bacterial panel consisted of Staphylococcus aureus, Escherichia coli, Klabsiella pneumoniae, Proteus vulgaris while fungal panel included of Aspergillus fumigatus (plant isolate), Candida glabrata, Candida albacans, Candida krusei. Ampicillin trihydrate and fluconazole were used as reference drugs for antibacterial and antifungal activity respectively. Bacterial and fungal inhibition determined by disk diffusion and serial plate dilution method respectively. Pathogenic inhibitions were determined by measuring the diameter of the inhibition zone in mm. Compound 4c demonstrated significant antibacterial and antifungal spectrum against all the tested microbes.

Keywords: antibacterial, antifungal and substituted 1,3,4-thiadiazoles

Author: Tilak Ram, Ranjana Dubey, Nidhi Chaudhary

Journal Code: jpfarmasigg160043

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