Paket Lengkap The In Vitro Antioxidant Properties Of 2-Alkoxyphenylcarbamic Acid Derivatives Containing A 4´-(Substituted Phenyl)Piperazin-1´-Yl Moiety Determined By The 2,2´-Azinobis(3-Ethylbenzothiazoline-6-Sulfonic Acid) Derived Radical Cation (Abts•+) And Ferric Re

Paket Lengkap The In Vitro Antioxidant Properties Of 2-Alkoxyphenylcarbamic Acid Derivatives Containing A 4´-(Substituted Phenyl)Piperazin-1´-Yl Moiety Determined By The 2,2´-Azinobis(3-Ethylbenzothiazoline-6-Sulfonic Acid) Derived Radical Cation (Abts•+) And Ferric Re - Hallo sahabat Paket Lengkap Pendidikan Dasar, Pada Artikel yang anda baca kali ini dengan judul Paket Lengkap The In Vitro Antioxidant Properties Of 2-Alkoxyphenylcarbamic Acid Derivatives Containing A 4´-(Substituted Phenyl)Piperazin-1´-Yl Moiety Determined By The 2,2´-Azinobis(3-Ethylbenzothiazoline-6-Sulfonic Acid) Derived Radical Cation (Abts•+) And Ferric Re, kami telah mempersiapkan artikel ini dengan baik untuk anda baca dan ambil informasi didalamnya. mudah-mudahan isi postingan Artikel Jp Farmasi gg 2017, yang kami tulis ini dapat anda pahami. baiklah, selamat membaca.

Judul : Paket Lengkap The In Vitro Antioxidant Properties Of 2-Alkoxyphenylcarbamic Acid Derivatives Containing A 4´-(Substituted Phenyl)Piperazin-1´-Yl Moiety Determined By The 2,2´-Azinobis(3-Ethylbenzothiazoline-6-Sulfonic Acid) Derived Radical Cation (Abts•+) And Ferric Re
link : Paket Lengkap The In Vitro Antioxidant Properties Of 2-Alkoxyphenylcarbamic Acid Derivatives Containing A 4´-(Substituted Phenyl)Piperazin-1´-Yl Moiety Determined By The 2,2´-Azinobis(3-Ethylbenzothiazoline-6-Sulfonic Acid) Derived Radical Cation (Abts•+) And Ferric Re

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Paket Lengkap The In Vitro Antioxidant Properties Of 2-Alkoxyphenylcarbamic Acid Derivatives Containing A 4´-(Substituted Phenyl)Piperazin-1´-Yl Moiety Determined By The 2,2´-Azinobis(3-Ethylbenzothiazoline-6-Sulfonic Acid) Derived Radical Cation (Abts•+) And Ferric Re


Abstract: In an effort to comprehensively characterize an antioxidant profile of 2-alkoxyphenylcarbamic acid-based compounds containing a 4´-(substituted phenyl)piperazin-1´-yl fragment, they were in vitro screened in the 2,2´-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) derived radical cation (ABTS•+) and ferric reducing antioxidant power (FRAP) assay using the UV/VIS spectrophotometry. The ABTS•+ scavenging (reducing) potential of 1-[3-(2-methoxyphenylcarbamoyl)oxy-2-hydroxypropyl]-4-(4-fluorophenyl)piperazin-1-ium chloride was found to be the most promising and it was comparable to the efficiency of the carvedilol reference drug. Moreover, that 4´-fluoro group-containing compound was regarded as more active than the atenolol standard. When testing the molecules´ power to reduce the ferric 2,4,6-tris (2-pyridyl)-s-triazine complex [Fe(III)(TPTZ)2]3+, the most prospective was 1-[3-(2-ethoxyphenylcarbamoyl)oxy-2-hydroxypropyl]-4-(4-fluorophenyl)piperazin-1-ium chloride. On the other hand, its Fe3+ reducing power was lower compared to both standards carvedilol and atenolol. The study discussed structure–antioxidant properties relationships considering electronic, steric and lipophilic features.
Keywords: Substituted phenylcarbamates; N-arylpiperazines; antioxidant properties; ABTS•+; FRAP; electronic features; lipophilicity
Author: Ivan Malík, Lukáš Stanzel, Jozef Csöllei, Jana Čurillová
Journal Code: jpfarmasigg170010


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